Описание: Adeno-associated viruses (AAVs) are the main viral vectors for gene therapy and have been successful in treating inherited retinal diseases and spinal muscular atrophy. An AAV is composed of an icosahedral protein shell with a single-stranded genome of approximately 4.7 kb. The intact AAVs act as a vehicle to protect and deliver oligonucleotide therapeutics. As AAVs continue to be explored as therapeutic delivery platforms, it is vital to ensure that all the critical quality attributes of the therapeutic product are maintained. This webinar highlights a workflow to characterize AAVs via LC/MS, including post-translational modification identification of the capsid proteins.
Лектор: Wendi Hale, Ph.D., Application Scientist, Agilent Technologies, Inc.
Дата: 13 януари 2021, 20:00 ч. българско време
Продължителност: 1 час
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