6230B Time of Flight LC/MS

The Agilent 6230 time-of-flight LC/MS (LC/TOF) system allows you to upgrade from unit mass measurements to accurate mass for even more confident compound identification beyond conventional LC/MS detection. You will get full-spectrum data for screening, profiling and identification of small molecules, large biologic compounds, and everything in between. Making the 6230B HPLC TOF ideal for applications like drug development, toxicology, and the analysis of intact proteins.

MS/MS applications are also supported by using fragments formed in the desolvation region of the TOF system’s ion source. All Ions MS/MS software then allows highly confident target compound identification by matching fragmentation patterns with an Agilent MS/MS library. Other advanced and intuitive software tools like one-click SWARM autotune and Walkup software allow anyone to routinely achieve reliable results. Producing expert-level results shouldn’t require expert-level training. With the Agilent 6230B time-of-flight LC/MS, it won’t.

  • Reduce false positives with better than 1 ppm mass accuracy.
  • Ensure excellent data quality even for fast UHPLC peaks in high-throughput workflows with data acquisition rates up to 44 spectra/second.
  • Identify compounds based on accurate mass, isotopic abundance, and chemical composition using Find by Formula in MassHunter software.
  • Analyze monoclonal Antibodies (mAb) with high mass accuracy and resolving power for glycoforms and truncation.
  • Characterize large biologic compounds with a broad mass range of up to 20,000 m/z.
  • Separate target compounds from interferences with high-resolution data.
  • Find impurities at extremely low concentrations, using Agilent Jet Stream technology with low picogram on-column sensitivity.
  • Identify trace-level target compounds in the presence of more abundant matrix compounds with up to five orders of in-spectrum dynamic range.
  • Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter Walkup software.
  • Perform untargeted screening with optional fragmentation data using in-source induced dissociation.
  • Go beyond UHPLC separation with support for capillary electrophoresis, SFC, 2D-LC, and even GC-APCI chromatographic interfaces.

Брошура

Why Stop at Detection Start Identifying_ Agilent 6230 LC/TOF System

Screening samples by HPLC enables rapid compound detection.

Brochures, English, 02 Nov 2018, 1.64 MB, PDF

 

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Monoclonal Antibody Charge Variants Identification by Fully Automated Capillary Isoelectric Focusing – Mass Spectrometry

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Comprehensive Food Profiling Combining High Resolution LC/MS and GC/MS Analysis

A comprehensive untargeted approach using high-resolution LC/MS and GC/MS was applied to study differences in food compositions from distinct diets.

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